Recombinant microorganisms for increased production of organic acids
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United States of America Patent
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Apr 30, 2013
Grant Date -
Jun 28, 2012
app pub date -
Dec 16, 2011
filing date -
Dec 22, 2004
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Abstract
Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
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