Method for evaluating the response of an individual to a treatment with a type I interferon (IFN)
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United States of America Patent
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Apr 23, 2013
Grant Date -
May 27, 2010
app pub date -
Jan 24, 2008
filing date -
Jan 25, 2007
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Expired
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Abstract
A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably MxA, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
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