Method to block the infection by flaviviruses, molecules and uses
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United States of America Patent
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Apr 16, 2013
Grant Date -
Sep 1, 2011
app pub date -
Apr 26, 2007
filing date -
Apr 28, 2006
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Abstract
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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