Muteins of hNGAL and related proteins with affinity for a given target
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United States of America Patent
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Apr 16, 2013
Grant Date -
Oct 27, 2011
app pub date -
Jun 24, 2009
filing date -
Jun 24, 2008
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Abstract
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
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