Importance

Loading Importance Indicators...

Abstract

Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R₃ is a radical of formula -(Alk¹)_m-(Z¹)_p-(Alk²)_n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is —O—, —S—, —S(O)—, —S(O₂)—, —NH—, —N(CH₃)—, —N(CH₂CH₃)—, —C(—O)—, —0—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk¹ and Alk² are optionally substituted C₁-C₆ alkylene, C₂-C₆ alkenylene, or C₂-C₆ alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O₂)—, —NH—, —N(CH₃)—, Or —N(CH₂CH₃)—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R₄ and R₅ are optional substituents; and R₂, R₆ and R₇ are independently hydrogen or a radical of formula -(Alk³)_x-(Z²)y-(Alk⁴)_z-H wherein x, y and z are independently 0 or 1, Z² is —O—, —S—, —S(O)—, —S(O₂)—, —NH—, —N(CH₃)—, —N(CH₂CH₃)—, —C(—O)—, —0—(C═O)— or —C(═O)—O—; Alk³ and Alk⁴ are optionally substituted C₁-C₃ alkylene, C₂-C₃ alkenylene, or C₂-C₃ alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O₂)—, —NH—, —N(CH₃)—, or —N(CH₂CH₃)—.

Loading the Abstract Image...

First Claim