Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations
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United States of America Patent
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Apr 9, 2013
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app pub date -
May 28, 1999
filing date -
May 29, 1998
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Abstract
Compositions of submicron- to micron-sized particles of water-insoluble biologically active substances that are stabilized by thermoprotecting agents, can be terminally steam sterilized without any significant increase of mean particle size. These compositions display markedly reduced heat-induced coagulation, flocculation, or particle size growth during the terminal steam sterilization process.
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