Method of detecting or monitoring a malignant plasma cell disease
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United States of America Patent
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Apr 9, 2013
Grant Date -
Jul 21, 2011
app pub date -
Jan 21, 2011
filing date -
Jan 27, 2005
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Abstract
A method of detecting or monitoring a malignant plasma cell disease comprising detecting in a sample the ratio between the relative amounts of immunoglobulins having:
- (i) a heavy chain class bound to λ light chains; and(ii) immunoglobulins having the same heavy chain class but bound to κ light chains. More particularly, in one embodiment the method comprises the steps of measuring the relative amounts of the respective immunoglobulins by using:(i) at least one antibody, or a fragment thereof, specific for the heavy chain class;(ii) an antibody, or a fragment thereof, specific for λ light chains; and(iii) an antibody, or a fragment thereof, specific for κ light chains.
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