Calcium phosphate granules of the hydroxyapatite type, their preparation process and their applications
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United States of America Patent
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Apr 9, 2013
Grant Date -
Jun 17, 2010
app pub date -
Dec 11, 2009
filing date -
Jul 16, 2003
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Expired
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Abstract
The invention concerns calcium phosphates in granular form having an x-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it comprises processing a suspension of brushite dicalcium phosphate having a certain particle-size distribution using a basic solution, and maintaining the pH at not less than 7.0 for a sufficient time interval to enable the transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.
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