Functional antagonists of hedgehog activity
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United States of America Patent
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Apr 2, 2013
Grant Date -
Sep 4, 2003
app pub date -
Jun 5, 2002
filing date -
Nov 2, 1998
priority date (Note) -
Expired
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Abstract
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the functional antagonists are also described.
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