Histamine H3 inverse agonists and antagonists and methods of use thereof
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United States of America Patent
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Mar 26, 2013
Grant Date -
Jan 26, 2012
app pub date -
Sep 29, 2011
filing date -
Feb 11, 2009
priority date (Note) -
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Abstract
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
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