Agents with angiogenic and wound healing activity

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United States of America Patent

PATENT NO 8404644
APP PUB NO 20100210531A1
SERIAL NO

12676295

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Abstract

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The invention relates to the use of angiogenic crystallin proteins to promote angiogenesis, wound healing and/or endothelial cell migration. Alpha A crystallin and βB2 crystallin have particular application in these methods. The crystallins will usually be in monomeric form. Typically, truncated form(s) of βB2 crystallin protein are utilized as can be prepared by partial hydrolysis of the protein by a protease enzyme such as elastase I. Methods for the purification of crystallin proteins from eye tissue are also described.

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Patent Owner(s)

Patent OwnerAddress
CALLAGHAN INNOVATION69 GRACEFIELD ROAD LOWER HUTT 5040

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Johnson, Keryn Wellington, NZ 4 11
Vasudevamurthy, Madhusudan Christchurch, NZ 1 8

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