biofilm production
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United States of America Patent
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Mar 19, 2013
Grant Date -
Jan 13, 2011
app pub date -
Jun 21, 2010
filing date -
Mar 31, 2006
priority date (Note) -
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Abstract
Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.
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