Autoantigenes for improved diagnosis, prognosis and treatment of inflammatory neurological diseases

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United States of America Patent

PATENT NO 8399210
APP PUB NO 20090252714A1
SERIAL NO

12420627

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Abstract

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According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective autoantigens identified. It can further be shown that many of these autoantigens are expressed specifically in the brain. The identification of the autoantigens and autoantibodies is useful for diagnosis and treatment. A brain-specific expression of the autoantigens further emphasizes an important role of the antigens and antibodies in the origin and development of neurological autoimmune diseases.

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Patent Owner(s)

Patent OwnerAddress
JOHANNES GUTENBERG-UNIVERSITAT MAINZ55128 MAINZ
GANYMED PHARMACEUTICALS AG A GERMAN CORPORATIONFREILIGRATHSTRASSE 12 MAINZ 55131

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sahin, Ugur Mainz, DE 331 2329
Türeci, Özlem Mainz, DE 76 516
Zaigler, Alexander Hainburg, DE 1 1

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