Composition for improving efficiency of drug delivery
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United States of America Patent
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Mar 5, 2013
Grant Date -
Aug 20, 2009
app pub date -
Sep 29, 2005
filing date -
Sep 29, 2004
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Abstract
Method and composition suitable for administering by direct convective interstitial infusion are disclosed. The method comprises: placing at least one direct convective interstitial infusion catheter in contact with the tissue, and pressuring the composition through the catheter. The composition is in a liquefied form having a viscosity above a predetermined value. The predetermined value is selected so as to improve infusion of the compositions into interstitial volumes of the tissue, while minimizing backflow of the compositions along an outer wall of the catheter or leakage into low resistance paths. It is demonstrated that high viscosity results in higher treatment efficiency.
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