Stabilized steroid composition and method for its preparation
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United States of America Patent
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Mar 5, 2013
Grant Date -
Sep 29, 2011
app pub date -
Jun 8, 2011
filing date -
Jan 23, 2003
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Abstract
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free acid or as a compound such as an ester. Specifically disclosed are methods for preventing the isomerization of hydrocortisone 17-butyrate into hydrocortisone 21-butyrate through the use of safflower oil.
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