Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
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United States of America Patent
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Feb 26, 2013
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May 17, 2012
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Jul 21, 2010
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Jul 28, 2009
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Abstract
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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