High affinity HIV T cell receptors
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United States of America Patent
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Feb 19, 2013
Grant Date -
Aug 27, 2009
app pub date -
Mar 29, 2006
filing date -
Apr 1, 2005
priority date (Note) -
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Abstract
The present invention provides TCRs having high affinity. The TCR binds to SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 with a KD of less than or equal to 1 μM and/or an off-rate (koff) of 1×10−3 S−1 or slower using Surface Plasmon Resonance. The TCRs are non-native, isolated or recombinant. The TCRs are useful, either alone, or with a therapeutic agent, for targeting HIV infected cells that present the SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 complex.
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