Purines as reverse transcriptase inhibitors
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United States of America Patent
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Feb 12, 2013
Grant Date -
Nov 1, 2012
app pub date -
May 11, 2012
filing date -
Dec 14, 2007
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Abstract
Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders. In some embodiments, the enzyme inhibitors are compounds of formula (I) or a pharmaceutically acceptable salt or tautomer thereof:
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