Method for detecting misfolded proteins and prions
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United States of America Patent
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Feb 12, 2013
Grant Date -
Apr 7, 2011
app pub date -
Feb 14, 2006
filing date -
Feb 15, 2005
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Abstract
The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.
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