Method for making 3α-hydroxy, 3β- substituted-5α-pregnan-20-ones

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Jan 29, 2013
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Feb 17, 2011
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Aug 11, 2010
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Aug 13, 2009

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Abstract

Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula

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IMMEDICA PHARMA US INC	150 N MICHIGAN AVENUE SUITE 1950 CHICAGO IL 60611

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C07J:STEROIDS

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Inventor Name	Address	# of filed Patents	Total Citations
Hutchison, Alan	Brick, US	115	2822
Shaw, Kenneth	Weston, US	73	3370

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Method for making 3α-hydroxy, 3β- substituted-5α-pregnan-20-ones

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United States of America Patent

12854226

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PATENT NO	8362286
APP PUB NO	20110040112A1
SERIAL NO	12854226
DOCKET NO

US Family Size	Non-US Coverage
Patent Longevity	Forward Citations

DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
January 29, 2013	US,8362286,B2 US8362286B2	GRANTED PATENT AS SECOND PUBLICATION
February 17, 2011	US,20110040112,A1 US20110040112A1	FIRST PUBLISHED PATENT APPLICATION

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12854226

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