Tricyclic derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)
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United States of America Patent
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Jan 29, 2013
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Mar 3, 2011
app pub date -
Mar 13, 2009
filing date -
Mar 14, 2008
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Abstract
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
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