Synthesis and anti-proliferative effect of substituted imidazo[4,5-b]pyrazine compounds
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United States of America Patent
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Jan 29, 2013
Grant Date -
Apr 19, 2012
app pub date -
Dec 20, 2011
filing date -
Feb 1, 2008
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status (Latency Note)
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Abstract
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. In particular, the disclosure provides for substituted imidazo[4,5-b]pyrazine compounds having the general formula
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