Synthesis and anti-proliferative effect of benzimidazole derivatives
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United States of America Patent
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Jan 22, 2013
Grant Date -
Apr 19, 2012
app pub date -
Dec 20, 2011
filing date -
Feb 1, 2008
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Abstract
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. In particular, the disclosure provides for substituted purine compounds having the general formula
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