HCV replicons containing NS5B from genotype 2B
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United States of America Patent
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Jan 15, 2013
Grant Date -
Oct 13, 2011
app pub date -
Nov 3, 2004
filing date -
Nov 5, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype 2b polymerase. Also featured is a genotype 1b NS4B adaptive mutation. The ability to produce replicons containing a functional genotype 2b NS5B is illustrated by the production of chimeric replicons based on HCV genotype 1b where substantially all the NS5B sequence is replaced with a genotype 2b NS5B.
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