Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)

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United States of America Patent

PATENT NO 8354413
APP PUB NO 20110207720A1
SERIAL NO

12673555

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Abstract

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The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

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Patent Owner(s)

Patent OwnerAddress
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI S R L00189 ROMA (RM)

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jones, Philip Rome, IT 185 2866
Kinzel, Olaf Rome, IT 37 738
Koch, Uwe Rome, IT 66 1102
Ontoria, Ontoria Jesus Maria Rome, IT 20 350
Pescatore, Giovanna Rome, IT 13 410
Scarpelli, Rita Rome, IT 28 440
Torrisi, Caterina Rome, IT 3 50

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