Mediators of hedgehog signaling pathways, compositions and uses related thereto
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United States of America Patent
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Jan 15, 2013
Grant Date -
Apr 21, 2005
app pub date -
Jul 29, 2002
filing date -
Jul 27, 2001
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Expired
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Abstract
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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