Polynucleotides encoding novel PCSK9 variants
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United States of America Patent
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Jan 15, 2013
Grant Date -
May 24, 2012
app pub date -
Dec 23, 2011
filing date -
Jun 30, 2006
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Abstract
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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