Salts of 4-aniline quinazoline derivative
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United States of America Patent
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Jan 8, 2013
Grant Date -
Jul 1, 2010
app pub date -
Feb 4, 2008
filing date -
Feb 14, 2007
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Abstract
The present invention relates to salt forms of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide as exemplified by formula (I), methods of preparation thereof, pharmaceutical compositions comprising the same and their use thereof. The salt forms of the present invention, which possess excellent tumor inhibitory activity, good bioavailability and low toxicity in an animal body, are suitable for use of preparation of anti-tumor medicaments.
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