Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
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United States of America Patent
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Jan 8, 2013
Grant Date -
Jun 26, 2008
app pub date -
Oct 10, 2007
filing date -
Oct 10, 2003
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Abstract
The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
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