Nucleic acid molecules encoding rage fusion proteins
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United States of America Patent
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Jan 1, 2013
Grant Date -
Nov 17, 2011
app pub date -
Jun 13, 2011
filing date -
May 5, 2006
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Abstract
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
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