Designer ubiquitin ligases having a non-cleavable SNAP25 domain and E3-ligase domain

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United States of America Patent

PATENT NO 8343743
APP PUB NO 20100015116A1
SERIAL NO

12482420

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Abstract

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The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.

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Patent Owner(s)

Patent OwnerAddress
SYNAPTIC RESEARCH LLC1448 SOUTH ROLLING ROAD BALTIMORE MD 21227

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Oyler, George A Baltimore, US 16 98
Tsai, Yien Che Frederick, US 9 46

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