Compounds having a potentiating effect on the activity of ethionamide and uses thereof
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United States of America Patent
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Dec 25, 2012
Grant Date -
Jun 9, 2011
app pub date -
Jul 4, 2007
filing date -
Jul 4, 2006
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Abstract
The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
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