Amines as small molecule inhibitors
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United States of America Patent
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Dec 25, 2012
Grant Date -
Nov 13, 2008
app pub date -
Feb 28, 2008
filing date -
Feb 28, 2007
priority date (Note) -
Expired
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Abstract
The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. The compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
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