Stable growth hormone liquid formulation
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United States of America Patent
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Dec 25, 2012
Grant Date -
May 29, 2008
app pub date -
Dec 13, 2004
filing date -
Dec 23, 2003
priority date (Note) -
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Abstract
The present invention is directed to stable liquid growth hormone formulations that remain stable after physical agitation, and after exposure to one or more freeze-thaw events. Formulations of the present invention can be stored long term at a variety of temperatures, even frozen. In the present invention, a combination of buffer and stabilizing agents, including a non-ionic surfactant (e.g., polysorbate 20), a polymer stabilizer (e.g., polyethylene glycol), and other optional stabilizers combine to provide unexpected stability to aqueous formulations of a growth hormone (e.g., human growth hormone).
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