Gonadotropin releasing hormone antagonists
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United States of America Patent
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Dec 11, 2012
Grant Date -
Apr 23, 2009
app pub date -
Jul 18, 2005
filing date -
Jul 16, 2004
priority date (Note) -
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Abstract
Antagonistic peptides of GnRH having improved water solubility are disclosed. These peptides are capable of suppressing serum testosterone levels in vivo to chemical castration levels of ≦0.5 ng/ml. Stable, filter sterilizable, non-gelling solutions containing the GnRH antagonists at least at levels typically used in sustained release formulations also are disclosed, as is a method of increasing the solubility of GnRH antagonist in a polymer containing dispersed phase, which method comprises addition of an acid to the dispersed phase.
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