Bioartificial liver system using bioreactor packed with gel beads
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United States of America Patent
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Dec 11, 2012
Grant Date -
May 27, 2010
app pub date -
Mar 28, 2008
filing date -
Mar 30, 2007
priority date (Note) -
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Abstract
The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
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