Assay methods for identifying glycogen synthase kinase 3 modulators
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United States of America Patent
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Dec 4, 2012
Grant Date -
Apr 7, 2011
app pub date -
Sep 28, 2010
filing date -
Sep 28, 2009
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Abstract
Methods and compositions for glycogen synthase kinase 3 assays continue to be required for detection of glycogen synthase 3 kinase, assessment of glycogen synthase 3 kinase activity and identification of modulators of glycogen synthase 3 kinase. Methods and compositions for glycogen synthase kinase 3 assays are provided herein based on the discovery of a previously unknown interaction between glycogen synthase 3 kinase and eukaryotic translation initiation factor 4E-binding protein 1 which serves as a substrate for glycogen synthase kinase 3-alpha and glycogen synthase kinase 3-beta.
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