Method of treating lewis Y-expressing tumors
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United States of America Patent
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Dec 4, 2012
Grant Date -
Jan 27, 2011
app pub date -
May 24, 2010
filing date -
Jul 14, 2004
priority date (Note) -
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Abstract
The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
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