Importance

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Abstract

Compounds of formula (I) R^A—CO—N(R²)—(CR¹₂)_n—N(R⁵)—R^B and salts or optical active isomers thereof, wherein each R¹ independently are the same or different and denotes a hydrogen atom, a hydroxyl group, a C₁ to C₄ straight of branched alkyl group or a C₁ to C₄ straight of branched oxyalkyl group; R² denotes a hydrogen atom or a C₁ to C₄ straight of branched alkyl group; R⁵ independently are the same or different and denotes a acyl moiety; R^A and R^B independently are the same or different and denote a triiodinated phenyl group, preferably a 2,4,6-triiodinated phenyl group further substituted by two groups R³ in the 3 and 5 positions wherein each R³ are the same or different and denote a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one R³ group in the compound of formula (I) is a hydrophilic moiety; and n denotes a positive integer of 1 to 6. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

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First Claim