Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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United States of America Patent
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Nov 27, 2012
Grant Date -
May 17, 2012
app pub date -
Mar 24, 2011
filing date -
Sep 19, 2003
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Abstract
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
- a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionallyb) isolating the obtained sulphoxide of formula (I).
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