Method of regulating glucose metabolism, and reagents related thereto
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United States of America Patent
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Nov 27, 2012
Grant Date -
Jul 14, 2011
app pub date -
Nov 9, 2010
filing date -
Feb 2, 1998
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Abstract
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to inhibit DPIV proteolysis of GLP-1 but not sufficient to suppress the immune system of the animal.
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