Patterning with compositions comprising lipid

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8318508
APP PUB NO 20090143246A1
SERIAL NO

12213301

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Abstract

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Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.

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Patent Owner(s)

Patent OwnerAddress
NORTHWESTERN UNIVERSITYEVANSTON IL 60208

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Ling Corning, US 138 3413
Lenhert, Steven Karlsruhe, DE 18 122
Mirkin, Chad A Wilmette, US 279 6087
Vega, Rafael Evanston, US 2 19

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