Optimized nucleic acid sequences for the expression of VB4-845
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United States of America Patent
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Nov 27, 2012
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Oct 21, 2010
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Sep 26, 2008
filing date -
Sep 27, 2007
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Abstract
An optimized nucleic acid sequence encoding the immunoconjugate VB4-845 is disclosed. Modifications to the original VB4-845 nucleic acid sequence include optimization of the sequences encoding the VH region, VL region, linkers and pseudomonas exotoxin A. The modifications improved the yield of VB4-845 in an Escherichia coli expression system.
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