Antibodies against human melanoma-associated chondroitin sulphate proteoglycan (MCSP)
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United States of America Patent
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Nov 27, 2012
Grant Date -
Dec 2, 2010
app pub date -
Sep 10, 2007
filing date -
Sep 8, 2006
priority date (Note) -
Expired
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Abstract
The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
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