Replication competent viruses capable of silencing virus inhibitory factor expression
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United States of America Patent
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Nov 27, 2012
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Oct 9, 2006
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Apr 15, 2004
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Abstract
Described is a replication-competent virus capable of replication and having lytic capacity in target cells. The virus comprises in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the target cells, operably linked to one or more expression control sequences, functional in the target cells. The use thereof in the preparation of a medicament and the use thereof in a method for lysing target cells expressing a virus inhibitory factor are also described.
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