Process for the production of daptomycin
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United States of America Patent
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Nov 20, 2012
Grant Date -
Feb 25, 2010
app pub date -
Jul 30, 2009
filing date -
Aug 1, 2008
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Abstract
The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents in the feeding solution.
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