Pharmacogenomics of blood pressure lowering agents
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United States of America Patent
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Nov 6, 2012
Grant Date -
Dec 31, 2009
app pub date -
Feb 2, 2006
filing date -
Feb 2, 2005
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Abstract
A method of determining a suitable blood pressure lowering treatment for an individual comprises a step of assaying a biological sample from the individual for the presence or absence of the C-5312T SNP in a distal enhancer region of the renin gene. The presence of at least one T allele is indicative of an increased response to a blood pressure lowering treatment selected from the group comprising: angiotensin-2-receptor blockers; ACE Inhibitors; aldosterone receptor blockers; and beta-receptor blockers. The absence of at least one T allele is indicative of an increased response to a blood pressure lowering treatment selected from the group comprising: renin inhibitors; calcium channel blockers; and diuretics.
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