Molecular in vitro diagnosis of breast cancer
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United States of America Patent
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Oct 30, 2012
Grant Date -
Jan 13, 2011
app pub date -
Jan 5, 2009
filing date -
Jan 4, 2008
priority date (Note) -
Expired
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Abstract
The invention relates to the use of a multiplicity of polynucleotide probe sets, the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of the multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, for determining the variation of expression at least 12 genes, and their variants when present, in order to diagnose the benign or malignant state of a breast tumor.
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