Device for binding a target entity to a bait entity and detection methods using the same
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United States of America Patent
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Oct 23, 2012
Grant Date -
Sep 10, 2009
app pub date -
May 12, 2005
filing date -
May 13, 2004
priority date (Note) -
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Abstract
The present invention pertains to a device for binding a target entity onto a bait entity that is immobilized on said device, comprising: a) a lipid layer having a negative net charge in an aqueous solution at a neutral pH; b) a two-dimensional matrix of anchoring complexes that are bound to said lipid layer, wherein each of said anchoring complexes comprises: (i) a fusion complex comprising an Annexin protein fused to a partner molecule; and (ii) a bait entity. It also concerns various uses of said device, including for detection and pharmaceutical purposes.
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