Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent
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United States of America Patent
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Oct 23, 2012
Grant Date -
Dec 2, 2010
app pub date -
May 25, 2010
filing date -
Aug 13, 2004
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Abstract
The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.
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